THE DIFFERENCE IN KETAMINE & ANTIDEPRESSANTS

Ketamine is a unique medication with properties that distinguish it from typical antidepressants.  While typical antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs), work by modulating the levels of certain neurotransmitters in the brain, ketamine operates through a different mechanism. 

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KETAMINE'S EFFECT ON DEPRESSION

Ketamine is a medication that has been used as an anesthetic for many years.  However, more recently, it has been found to have rapid and effective antidepressant effects, particularly in treatment-resistant depression.  The exact mechanism by which ketamine helps depression is not fully understood, but research suggests that is works by modulating the activity of certain neurotransmitters in the brain, particularly glutamate. 

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WHICH METHOD OF KETAMINE DELIVERY IS MOST EFFECTIVE?

I frequently get asked “which method of ketamine delivery is the most effective?  Intravenous (IV), a shot into the muscle (IM) or nasal spray?”

Both intravenous (IV) and intramuscular (IM) ketamine and nasal spray have been sued to treat depression, although IV ketamine is generally considered the gold standard due to its faster onset and more consistent dosing.

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